Category: Weight Loss

As many as 50 percent of the world’s population are deficient in this vitamin.

High levels of vitamin D in the body are linked to weight loss and losing more belly fat, research finds.

One study has found that drinking more milk, which contains calcium and vitamin D, can double weight loss.

Higher levels of the vitamin may help the body to decrease the storage of fat.

On the other hand, low levels are linked to fat storage.

People on a diet have been shown to lose 20 pounds more when their vitamin D levels are high.

The current study included 90 young US women in California whose weight and vitamin D levels were tested.

The results revealed that low levels of vitamin D were linked to being shorter and heavier.

Dr Richard Kremer, the study’s first author, said:

“The high prevalence of vitamin D insufficiency in young people living in a sun-rich area was surprising.

We found young women with vitamin D insufficiency were significantly heavier, with a higher body mass index and increased abdominal fat, than young women with normal levels.”

Vitamin D is linked to the neurotransmitter serotonin, which is involved in many vital bodily processes, including mood and sleep.

Dr. Vicente Gilsanz, study co-author, said:

“Clinicians need to identify vitamin D levels in younger adults who are at risk by using a simple and useful blood test.

Because lack of vitamin D can cause fat accumulation and increased risk for chronic disorders later in life, further investigation is needed to determine whether vitamin D supplements could have potential benefits in the healthy development of young people.”

Vitamin D deficiency has also been linked to cardiovascular diseases, autoimmune diseases and a higher chance of getting colds.

Foods that are rich in vitamin D include oily fish and eggs, but most people get their vitamin D from the action of sunlight on the skin.

The study was published in the Journal of Clinical Endocrinology & Metabolism (Kremer et al., 2008).

These weight loss drugs have been found to increase the risk of pancreatitis and other serious digestive disorders.

Semaglutide (Wegovy, Ozempic, and Rybelsu) and liraglutide (Victoza and Saxenda) are GLP-1 agonists drugs which have been lauded for their weight loss effect.

However, a study has revealed that these popular antidiabetic drugs increase the risk of severe gastrointestinal disorders.

Semaglutide and liraglutide belong to a class of medications that copy the glucagon-like peptide 1 (GLP-1) hormone in order to control blood sugar levels and reduce hunger in people with diabetes.

Despite their anti-obesity effects, increased risk of gastrointestinal problems such as bowel obstruction, stomach paralysis, and pancreatitis is concerning.

Mr Mohit Sodhi, the study’s first author, said:

“Given the wide use of these drugs, these adverse events, although rare, must be considered by patients thinking about using them for weight loss.

The risk calculus will differ depending on whether a patient is using these drugs for diabetes, obesity or just general weight loss. People who are otherwise healthy may be less willing to accept these potentially serious adverse events.”

Unaware of side-effects

GLP-1 drugs are designed to help treat type-2 diabetes, but in the United States there were 40 million prescriptions for weight loss in 2022.

The clinical trials focused only on the drug’s effectiveness for weight loss and so many are not aware of the gastrointestinal side-effects.

Dr. Mahyar Etminan, the study’s senior author, said:

“There have been anecdotal reports of some patients using these drugs for weight loss and then presenting with repeated episodes of nausea and vomiting secondary to a condition referred to as gastroparesis.

But until now, there hasn’t been any data from large epidemiologic studies.”

The study used the records of 16 million American patients, comparing the incidence of gastrointestinal adverse events in liraglutide or semaglutide users with those using bupropion-naltrexone (a weight loss medication sold under brand name Contrave).

The data analyses showed that for the GLP-1 drugs:

• the risk of pancreatitis was 9.09 times higher compared to bupropion-naltrexone,
• the risk of bowel obstruction was 4.22 times higher,
• and the risk of gastroparesis or stomach paralysis was 3.67 times higher.

Severe abdominal pain

Pancreatitis is inflammation of the pancreas followed by severe abdominal pain: sometimes hospital admission and surgery is required.

Bowel obstruction is a disorder in which food can’t pass through the small or large intestine, causing symptoms such as vomiting, nausea, bloating, and cramping.

Gastroparesis, or stomach paralysis, is a disorder in which the movement of food slows down from the stomach to the small intestine causing symptoms such as abdominal pain, vomiting, and nausea.

Despite the rarity of side-effects (since millions are taking the medications), hundreds of thousands of people could still experience these issues.

Mr Sodhi said:

“These drugs are becoming increasingly accessible, and it is concerning that, in some cases, people can simply go online and order these kinds of medications when they may not have a full understanding of what could potentially happen.

This goes directly against the mantra of informed consent.”

Related

• Semaglutide could be an effective weight loss medication.
• Ozempic lowers blood sugar and increases weight loss.
• GLP-1 agonists that treats obesity may also help to destroy cancer cells.

The study was published in Journal of the American Medical Association (Sodhi et al., 2023).

Studies have linked a range of natural supplements to increased weight loss.

A number of different natural supplements have been linked to weight loss by research.

Drinking from two to four cups of green tea per day has been repeatedly linked to weight loss.

Those drinking four cups a day lost 5.5 pounds across eight week in one study.

Adding additional exercise on top may boost weight loss even further.

Green tea may be effective because it helps to regulate glucose levels.

The active ingredient is a type of flavonoid called gallated catechins, also known as EGCG.

However, if you are going to take a green tea supplement then beware of the side-effects, such as liver toxicity.

Dr Josh Lambert, the study’s first author, said:

“No person can sit down and drink 16 cups of green tea all at once.

However if you take a supplement you can get that type of green tea extract dose, so there is some indication that the dosage form has an influence on the potential to cause liver toxicity.”

One way of reducing the chance of liver toxicity from taking too much green tea is to begin drinking green tea weeks before taking the supplement.

The conclusions come from a study that compared two groups of mice.

One group was pretreated with low doses of green tea extract before being given higher doses later on.

The results showed that pretreatment with a lower dose reduced the chance of liver toxicity by 75 percent.

Dr Lambert said:

“We believe this study indicates that those who are chronic green tea consumers would be less sensitive to potential liver toxicity from green-tea-based dietary supplements.

If you are going to take green tea supplements, drinking green tea for several weeks or months ahead of time may reduce your potential side effects.”

A better option, Dr Lambert thinks is to drink green tea instead:

“Drinking green tea rather than taking supplements will allow you to realize the benefits and avoid the risk of liver toxicity.

The beneficial effects that people have reported as being associated with green tea are the result of dietary consumption rather than the use of supplements.

The relative risk of using supplements remains unclear.”

The study was published in the journal Food and Chemical Toxicology (James et al., 2015).

Reducing weight and potentially helping to fight cancer.

Semaglutide (marketed as Wegovy, Rybelsus and Ozempic) is a glucagon-like peptide-1 (GLP-1) receptor agonist that causes the body to produce more insulin.

The drug has been found to help diabetic patients in losing weight as well as reducing blood sugar levels.

Here are the results of three recent studies showing the potential of this drug.

Click the links in each section to get a fuller description of the study and its results.

1. 20 percent weight loss

A weekly injection of semaglutide, known as Ozempic, can reduce body weight by more than 20 percent, a study has found.

Semaglutide — which is now approved by the US FDA for weight management — is known as an anti-diabetic medication and typically prescribed in 1mg doses.

For this study, participants who were obese or overweight received a higher dose at 2.4 mg alongside a low calorie diet and increased physical activity.

Participants, on average, lost over 15 kg and more than 30 percent of people lost one-fifth of their weight — an equivalent of 20 percent.

2. Destroy cancer cells

Glucagon-like peptide (GLP-1) drugs such as Ozempic are best known for their weight loss effect and their capability of keeping blood sugar levels under control in people with type 2 diabetes.

However, one study has shown that it can produce improvements in the cancer-killing effect of NK cells and this is independent of weight loss so it can be a useful drug for immunotherapy against cancer.

NK cells are part of the immune system with anticancer properties, but obesity reduces their ability of producing cytokines and killing cancer cells.

3. Increase weight loss 75%

A study has compared the effectiveness of the currently approved 14 milligrams (mg) dose in adults with 25 mg, or 50 mg per day for 52 weeks.

The results showed that taking a 25 mg or 50 mg semaglutide tablet once a day is superior to the 14 mg dosage in reducing blood sugar levels and in increasing weight loss.

At the end of study period, participants who were on 50 mg of oral semaglutide had lost 17.5 pounds (8 kg), those on 25 mg had lost 14.8 pounds (6.7 kg), and those on 14 mg had lost 10 pounds (4.5 kg).

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People in the study lost an average of nine pounds using the diet.

People on an intermittent fasting diet lose more weight than those following the Mediterranean or paleo diets, research finds.

Broadly, there are two types of intermittent fasting.

The first type involves restricting the time of day during which people can eat.

For example, breakfast is taken 90 minutes later than usual and supper 90 minutes earlier, with nothing outside this 6 to 8 hour window.

The other approach involves only eating one meal on two days of the week, then eating normally the rest of the week (sometimes known as the 5:2 diet).

People in the current study lost an average of nine pounds using the intermittent fasting diet, more than double that of the paleo diet.

Those on the Mediterranean diet lost 6 pounds, on average, while those on the paleo diet lost 4 pounds on average.

However, people on the Mediterranean diet, while losing less weight, found it easier to follow and showed improvement in their blood pressure.

The conclusions come from a study that compared the three diets in a ‘real-world’ setting, without support from professionals.

There was evidence that all three diets could be healthy ways to eat.

Dr Melyssa Roy, study co-author, said:

“This work supports the idea that there isn’t a single ‘right’ diet—there are a range of options that may suit different people and be effective. In this study, people were given dietary guidelines at the start and then continued with their diets in the real world while living normally.

About half of the participants were still following their diets after a year and had experienced improvements in markers of health.

Like the Mediterranean diet, intermittent fasting and paleo diets can also be valid healthy eating approaches—the best diet is the one that includes healthy foods and suits the individual.”

The results showed that the Mediterranean diet was the easiest to follow.

Dr Michelle Jospe, the study’s first author, said:

“Our participants could follow the diet’s guidelines more closely than the fasting and paleo diets and were more likely to stay with it after the year, as our retention rates showed.”

The Mediterranean diet typically involves eating more fruits and vegetables, legumes, seeds, olive oil and fish, eggs, chicken and, once a week, red meat.

The paleo diet focuses on less processed foods including fruits and vegetables, animal proteins and extra-virgin olive oil.

The paleo diet prohibits legumes, grains and dairy.

However, people in the study used a modified version of the paleo diet that allows some dairy.

The study was published in The American Journal of Clinical Nutrition (Jospe et al., 2019).

Could water fasting increase weight loss and how many days consuming nothing but water is safe?

Water fasting is a type of diet plan undertaken by people who want to lose more weight quickly.

A water fast can last for five days or more and during this period a person will eat nothing but drink water and natural zero calorie beverages.

Scientists have reviewed the evidence for water fasting and Buchinger fasting, a medically supervised diet therapy consisting of taking very little food for several days to almost three weeks.

The research reveals that fasting for five to 20 days increases ketones production due to the body breaking down fat for energy, and promotes weight loss up to ten percent of body weight.

However, four months after the fast ends, the metabolic benefits such as reduced blood pressure, reduced LDL (bad) cholesterol and triglycerides, improved insulin sensitivity and blood sugar levels seem to fade.

The adverse effects were metabolic acidosis (too much acid in the body), insomnia, hunger, and headaches.

Otherwise, a water fast or a similar diet therapy where a person consumes very few calories daily did not cause any severe injury.

Professor Krista Varady, the study’s lead author, said:

“My overall conclusion is that I guess you could try it, but it just seems like a lot of work, and all those metabolic benefits disappear.”

Five days maximum

However, Professor Varady advised that without medical supervision, people should not use these type of fasts for more than five days.

The review analysed eight studies on prolonged water fasting or Buchinger fasting where fasters under medical supervision consume a tiny amount of vegetable soup, juice, tea, and water.

The findings show that the weight loss effect after a short period of time was visible.

In five days participants lost four to six percent of their weight, those on seven to 10 days fasting lost between two to 10 percent, and those on 15 to 20 days fasting slimmed down by seven to 10 percent.

After the fasting period was over, participants maintained their weight loss if they followed a restrictive calorie intake, otherwise in three months they gained the weight back.

About one-third of the weight loss was fat mass and two-thirds was lean mass suggesting that extreme fasts cause people to lose more muscle than body fat.

Professor Varady said:

“Your body needs a constant intake of protein.

If it doesn’t have that, then it draws from muscles.”

Professor Varady added she prefers those who want to lose weight to consider intermittent fasting instead of water fasting,

“Because there’s a lot more data to show it can help with weight management.”

Related

• Portion control is a better strategy for weight management than intermittent fasting.
• Continuous dieting and intermittent fasting lead to the same amount of weight loss.
• Mediterranean, low-carb, low-fat, or intermittent fasting, dieters lose the same amount of weight.
• The 16:8 diet is an effective way to lose weight.
• A 14-day break from dieting helps increase weight loss by 50 percent.
• Alternate day fasting and the 5:2 diet are more effective than time-restricted eating.

The study was published in the journal Nutrition Reviews (Ezpeleta et al., 2023).

Fewer small meals or intermittent fasting, which is more effective for losing weight?

Portion control or simply eating fewer calories appears to be a better strategy for weight management than intermittent fasting.

Eating less frequently and having smaller meals each day will strongly influence weight loss compared to fasting for a certain number of hours a day, a study has found.

Some studies have suggested that time‐restricted eating, also known as intermittent fasting, can boost circadian rhythms and energy metabolism.

However, the current study didn’t find that limiting meals for a specific period of time can helped anybody lose weight in the long run.

The research team examined the relationship between time from first to last meal with weight change.

For this study, 550 obese adults were enrolled, of which 80 percent were white, most participants had a college or higher degree.

The follow-up period was 6 years.

They used a mobile application to report eating, sleeping, and wake up time across 24 hours.

This information allowed the team to calculate the interval from waking to first meal, between meals, and from the last meal to sleep.

Summary of findings

• Meal timing had no effect on weight change over the long-term.
• Total daily number of large meals (more than 1,000 calories) was linked to weight gain over the six-year follow up.
• Total daily number of medium meals (between 500 to 1000 calories) was associated with weight gain over follow‐up time.
• However, fewer small meals (less than 500 calories) was linked to weight loss over the follow-up period.
• The time intervals from being awake to first meal was 1.6 hours, from first to last meal was 11.5 hours, and from last meal to sleep was 4 hours.
• Sleep duration on average made up 7.5 hours of the 24-hour window each day.
• The greatest risk factors for weight change were daily calorie intake and meal frequency rather than meal timing.

Data suggests that nearly 70 percent of Americans are either overweight or obese, a serious risk factor for cardiovascular disease and diabetes.

Therefore, improving diet and lifestyle, including eating healthy foods, lower calorie intake, smaller sized meals, more physical activity, less stress, and better sleep can help people to battle obesity.

According to the American Heart Association, irregular eating patterns and changing meal frequency are not favourable for weight control and heart health.

The study was published in the Journal of the American Heart Association (Zhao et al., 2023).

The daily amount of Ozempic that lowers blood sugar and increases weight loss.

People with type 2 prediabetes don’t respond to insulin and as the condition progresses, lowering blood glucose and losing weight becomes difficult.

A healthy diet and exercise could certainly reduce the risk of diabetes but when it comes to medication there are many ups and downs.

Semaglutide (marketed as Wegovy, Rybelsus and Ozempic) is a glucagon-like peptide-1 (GLP-1) receptor agonist that causes the body to produce more insulin.

The drug has been found to help diabetic patients in losing weight as well as reducing blood sugar levels.

While the drug keeps gaining attention, the effective dosage of oral semaglutide has been challenged.

Semaglutide dosage study

A study compared the effectiveness of the currently approved 14 milligrams (mg) dose in adults with 25 mg, or 50 mg per day for 52 weeks.

The results showed that taking a 25 mg or 50 mg semaglutide tablet once a day is superior to the 14 mg dosage in reducing blood sugar levels and in increasing weight loss.

At the end of study period, participants who were on 50 mg of oral semaglutide had lost 17.5 pounds (8 kg), those on 25 mg had lost 14.8 pounds (6.7 kg), and those on 14 mg had lost 10 pounds (4.5 kg).

Semaglutide suppresses appetite so as the dosage increases there will be less desire for eating which results in losing more weight.

Professor John Buse, the study’s lead author, said:

“Low doses of GLP-1 receptor agonists are really powerful for reducing A1C, or the average glucose in the blood.

Whereas, the higher doses that are really good for weight reduction.

On average, patients lost eight kilograms (17.5 lbs) at 50 milligrams, which is nearly twice as much weight loss that we saw with the lowest dose.”

The common side effects for semaglutide are nausea, vomiting, diarrhoea, or constipation which occurred more often with taking daily dosages of 25 mg or 50 mg.

The trial involved more than 1,600 adults with type 2 diabetes who were randomly divided into three groups by the daily dosage of oral semaglutide; 14 mg, 25 mg, and 50 mg.

The haemoglobin A1c (HbA1c) test reflects blood glucose levels and the A1c for adults with diabetes is suggested to be below 7 percent.

In this study, participants A1c levels were between 8 to 10.5 percent.

They found that those who received either 25 mg or 50 mg of oral semaglutide were more likely to reach the goal (A1c level of below 7 percent).

Related

• Weekly injections of semaglutide reduces body weight by more than 20 percent.
• Injection of 2.4 mg of semaglutide with a low-calorie diet can lead to a weight loss of 37 lb.
• Glucagon-like peptide (GLP-1) drugs treat obesity and may help to destroy cancer cells.

The study was published in the The Lancet (Aroda et al., 2023).

This diet is a very effective weight loss strategy for diabetic patients and those with prediabetes.

People with type 2 diabetes are often obese or overweight and have high blood pressure.

However, to combat this metabolic syndrome, the first step is to lose weight.

There are several effective diet plans to help people with this condition but what dieting strategy works best remains unclear.

A study on adults with type 2 diabetes has found that time restricted eating (TRE) is more effective than the daily calorie restriction (CR) strategy.

TRE is a type of intermittent fasting that only allows an eating window of 8 to 12 hours and water fasting during the remaining hours each day.

The TRE group in this study were allowed to eat between noon to 8pm while the other group followed the CR approach.

Participants on the TRE regime lost more weight and body fat, and saw an increase in HDL (good cholesterol) compared to those who ate fewer calories.

However, blood sugar levels were similarly improved in both groups.

Ms Vicky Pavlou who presented this research at the annual meeting of the American Society for Nutrition, said:

“Many people find counting calories very hard to stick to in the long term, but our study shows that watching the clock may offer a simple way to decrease calories and lose weight.

Although time-restricted eating is becoming increasingly popular, no other studies have looked at an eight-hour eating window in people with type 2 diabetes.”

Professor Krista Varady and the team wanted to know if diabetic people would gain more benefits from the TRE strategy than the CR diet plan.

57 overweight and obese adults with type 2 diabetes were divided into calorie restriction, time-restricted eating, and control groups.

The TRE group were allowed to eat for 8 hours (noon to 8 p.m.), the CR group could eat at any time but counted their daily calorie intake, but the control group could eat whenever and as much as they liked.

When compared with the control and the CR groups over six months, participants on the TRE diet lost about 4 percent of their weight, equivalent of losing 5 kg for a person weighing 125 kg.

Haemoglobin A1c (HbA1c) levels were tested for blood sugar, the normal range is 4 to 5.6 percent but the levels in people with diabetes were 6.5 percent.

The results show that the HbA1c levels for the TRE group reduced by 0.91 percent and for the CR group by 0.95 percent.

To see any improvement in cardiometabolic risk factors a minimum 5 percent weight loss is required.

Since this was not achieved, the team could not assess them.

Ms Pavlou added:

“Our study shows that time-restricted eating can be a good alternative for those with type 2 diabetes who want to lose weight and improve their blood sugar.

However, there are multiple types of medications for those with type 2 diabetes, some of which can cause low blood sugar and some that need to be taken with food.

Therefore, it is important to work closely with a dietitian or doctor when implementing this dieting approach.”

Related

• Intermittent fasting causes mild to moderate weight loss.
• A 14-day break from dieting increases weight loss by 50%.
• Intermittent fasting can lead to the same amount of weight loss as regular calorie restriction.
• Continuous dieting and intermittent fasting weight loss techniques are equally effective.

The study was presented at the annual meeting of the American Society for Nutrition in Boston (Pavlou et al., 2023).

People who consume their daily calories in this way can double weight loss.

Eating high quality proteins like eggs, Greek yogurt and lean meats for breakfast can boost weight loss, research finds.

Having more calories for breakfast has even been linked to more than doubling weight loss, one study has found.

Consuming more calories at breakfast is linked to a greater chance of losing weight and reducing the waistline.

Even having a desert at breakfast, such as a cookie or piece of chocolate cake, was linked by the previous study to lower levels of insulin later on and healthier triglyceride levels.

In general, people who consume their daily calories earlier in the day can double weight loss.

Despite this, more than half of young people skip breakfast, researchers find.

This is what inspired Dr Heather Leidy, co-author of the current study:

“This study examined if the type of breakfast consumed can improve weight management in young people who habitually skip breakfast.

Generally, people establish eating behaviors during their teen years.

If teens are able to develop good eating habits now, such as eating breakfast, it’s likely to continue the rest of their lives.”

The study included 28 overweight teens, half of whom were fed a high-protein breakfast (35g) and half a normal-protein breakfast (13g).

Normal protein breakfasts involved milk and cereal while high-protein breakfasts included eggs, dairy and lean pork.

All the teenagers in the study reported skipping breakfast almost every day of the week.

Dr Leidy explained the results:

“The group of teens who ate high-protein breakfasts reduced their daily food intake by 400 calories and lost body fat mass, while the groups who ate normal-protein breakfast or continued to skip breakfast gained additional body fat.

These results show that when individuals eat a high-protein breakfast, they voluntarily consume less food the rest of the day. In addition, teens who ate high-protein breakfast had more stable glucose levels than the other groups.”

The study was published in the International Journal of Obesity (Bauer et al., 2015).