Red Wine Headaches Explained: This Flavonoid Could Be To Blame

The flavonoid interferes with the metabolism of alcohol.

The flavonoid interferes with the metabolism of alcohol.

The intense hangover after drinking large amounts of alcohol is related to genetics, metabolism of alcohol (ethanol), sulphites, and congeners (compounds created by ethanol fermentation).

But wine products also contain other substances including tannins and histamine that can trigger headaches.

But when it comes to the “red wine headache” phenomena, there might be a different explanation.

Quercetin

Scientists think there must be other reasons that some people who are not heavy drinkers experience red wine headaches.

These headaches can occur 30 minutes to three hours after drinking a small glass of red wine.

Researchers came up with a theory that an antioxidant called quercetin may trigger headaches by interfering with the metabolism of alcohol.

That makes sense since quercetin levels are much higher in red wine than other alcoholic drinks, including white wine.

Professor Andrew Waterhouse, the study’s senior author, explains how this healthy flavonoid interferes with alcohol:

“When it gets in your bloodstream, your body converts it to a different form called quercetin glucuronide.

In that form, it blocks the metabolism of alcohol.”

Toxin acetaldehyde

Ethanol is converted to toxic acetaldehyde in the body and than is metabolized by the ALDH2 enzyme to acetate.

If this fails than the acetaldehyde toxin would build up in the body causing symptoms such as headache, nausea, facial flushing, and excessive sweating.

Ms Apramita Devi, the study’s first author, said:

“Acetaldehyde is a well-known toxin, irritant and inflammatory substance.

Researchers know that high levels of acetaldehyde can cause facial flushing, headache and nausea.”

Nearly half of East Asian population experience these symptoms after a drink because their enzyme doesn’t work properly and so toxins builds up in their body.

Alcoholics who take drugs such disulfiram to overcome drinking also experience similar symptoms because the medication blocks the enzyme that breaks down acetaldehyde.

This study suggests that quercetin produces similar adverse effects by blocking ALDH2 which would result in accumulation of the toxin.

Professor Morris Levin, study co-author, said:

“We postulate that when susceptible people consume wine with even modest amounts of quercetin, they develop headaches, particularly if they have a preexisting migraine or another primary headache condition.”

Grapes and the sunshine

The higher the exposure to sunlight, the more flavanol in red grapes.

Normally red wines with better quality are produced from grapes that are grown with care and in sunnier climates.

Therefore, these type of grapes contain greater levels of quercetin.

The levels are also influenced by the process of wine making such as removing unwanted material known as fining, skin contact during fermentation, and aging.

Professor Waterhouse said:

“Quercetin is produced by the grapes in response to sunlight.

“If you grow grapes with the clusters exposed, such as they do in the Napa Valley for their cabernets, you get much higher levels of quercetin.

In some cases, it can be four to five times higher.”

Related

The study was published in the journal Scientific Reports (Devi et al., 2023).

2 Antioxidant Vitamins Reduce Vascular Dementia Risk By 88%

Cognitive performance is improved by taking these antioxidant vitamins regularly over the years.

Cognitive performance is improved by taking these antioxidant vitamins regularly over the years.

Antioxidants vitamin C and E may help to protect against some forms of dementia and improve cognitive performance over the lifespan, a study finds.

The research on over 3,000 Japanese-American men found that those taking vitamin C and E supplements regularly — at least once per week — were 88 percent less likely to have vascular dementia four years later.

Vascular dementia is the second most common from of dementia in the US, after Alzheimer’s disease.

The study also found that the men were 69 percent less likely to have other forms of dementia, apart from Alzheimer’s.

Dr Kamal Masaki, the study’s first author, said:

“We believe antioxidants like vitamin E and C may protect against vascular dementia by limiting the amount of brain damage that persists after a stroke.

The supplements may also play a role in providing protection against brain cell and membrane injury involved in many aging-related diseases, thus resulting in significantly higher scores on mental performance tests in later life.”

The Honolulu-based study also found that men taking the supplements had a 75 percent better chance of improved cognitive performance in later life.

However, the beneficial effect was not through the reduction in risk of stroke, Dr Masaki explained:

“We originally thought that the beneficial impact antioxidant vitamin supplements had against vascular dementia was the prevention of stroke.

However, to our surprise we found there was not a significant association between vitamin supplement use and clinically recognized stroke.”

Researchers did not find a protective effect of vitamin C and E supplementation on Alzheimer’s disease.

Dr Masaki said:

“It is critically important for patients to practice preventive efforts shown to lower stroke risk and to have broad ranging beneficial effects.

More effective strategies for prevention also must be found.

Therefore, a prevention trial of both vitamin E and C to further examine the potential protective effects on both vascular dementia and Alzheimer’s disease is needed.”

The study was published in the journal Neurology (Masaki et al., 2000).

5 Foods Science Says Will Help You Live Longer

The foods that help you live longer and protect you from cancer and heart disease.

The foods that help you live longer and protect you from cancer and heart disease.

Drinking tea and eating apples, or any flavonoid-rich foods, can shield people from cancer and heart disease, research finds.

People who have a daily consumption of 500 mg of flavonoids are more likely to live longer and more healthily.

If you eat one orange, one apple, 100 g of broccoli and 100 g of blueberries and have a cup of tea per day, you are guaranteed to obtain 500 mg of flavonoids.

Flavonoids are antioxidants and part of the polyphenol class found in plants and known to have several health benefits and help prevent various diseases.

Apples, cherries, dark chocolate, pears, tea, red wine (due to grapes), cabbage, and berries, including blueberries and strawberries, are good sources of flavonoids.

The discovery of flavonoids’ protective effect on lowering risk of some diseases comes from a new study that looked into the diets of 53,048 Danes over 23 years.

Dr Nicola Bondonno, the study’s lead author, said:

“It’s important to consume a variety of different flavonoid compounds found in different plant based food and drink.

This is easily achievable through the diet: one cup of tea, one apple, one orange, 100g of blueberries, and 100g of broccoli would provide a wide range of flavonoid compounds and over 500mg of total flavonoids”.

They found that those who ate flavonoid-rich foods were protected against cardiovascular and cancer-related diseases.

They also found that daily intake of flavonoid-rich foods had the most protective effect for heavy drinkers and smokers.

These smokers or those who had two standard alcoholic drinks per day were at higher risk of chronic diseases.

The reason is that smoking and alcohol intake can harm blood vessels and cause inflammation to the cells, leading to greater risk of serious diseases.

The potential health benefits of flavonoids are related to their antioxidants having anti-inflammatory effects and their ability to improve blood vessel function.

This may explain why the smokers and drinkers benefited strongly from foods rich in flavonoids.

Dr Bondonno said:

“It’s also important to note that flavonoid consumption does not counteract all of the increased risk of death caused by smoking and high alcohol consumption.

By far the best thing to do for your health is to quit smoking and cut down on alcohol.

We know these kind of lifestyle changes can be very challenging, so encouraging flavonoid consumption might be a novel way to alleviate the increased risk, while also encouraging people to quit smoking and reduce their alcohol intake.”

The study was published in Nature Communications (Bondonnoet al., 2019).

A Strange Sensation That Could Be A Sign Of Vitamin D Deficiency

Many people experience this unusual sensation even with both feet firmly on the ground.

Many people experience this unusual sensation even with both feet firmly on the ground.

A sudden sensation of dizziness, or that your head is spinning could be a sign of vitamin D deficiency.

It is a symptom of a common type of vertigo called paroxysmal positional vertigo (BPPV).

Other symptoms include nausea and vomiting, as well as a loss of balance.

However, taking vitamin D and calcium supplements twice a day can reduce the chance of experiencing vertigo, research finds.

The people who are most deficient in vitamin D get the most benefit from it.

Technically, vertigo is the symptom of dizziness and the feeling of the world spinning — it does not have to be in response to heights.

Many people experience vertigo with both feet firmly on the ground.

The condition is rarely serious, but can be very irritating, with 86 percent of sufferers reporting that it interrupts their daily life and leads to some days off work.

Now, research finds that taking vitamin D and calcium supplements can prevent it recurring.

Dr Ji-Soo Kim, study co-author, said:

“Our study suggests that for people with benign paroxysmal positional vertigo, taking a supplement of vitamin D and calcium is a simple, low-risk way to prevent vertigo from recurring.

It is especially effective if you have low vitamin D levels to begin with.”

The study included almost one thousand people, around half of whom were given vitamin D supplements and calcium.

People with low vitamin D levels took 400 IU of vitamin D and 500 mg of calcium twice a day.

The results showed that the supplements reduced the recurrence of vertigo by 24 percent.

People who were more deficient in vitamin D got greater benefit from taking the supplements, seeing a 45 percent reduction in symptoms.

Dr Kim said:

“Our results are exciting because so far, going to the doctor to have them perform head movements has been the main way we treat benign paroxysmal positional vertigo.

Our study suggests an inexpensive, low-risk treatment like vitamin D and calcium tablets may be effective at preventing this common, and commonly recurring, disorder.”

The study was published in the journal Neurology (Jeong et al., 2020).

The Common Signs Of Vitamin D Deficiency

Vitamin D deficiency is more common in winter.

Vitamin D deficiency is more common in winter.

Tiredness, depression and weak muscles can all be signs of vitamin D deficiency.

Depression risk is raised by vitamin D deficiency, according to one study.

This may be because of the role that vitamin D plays in regulating serotonin.

Serotonin is a neurotransmitter important for mood.

Similarly, poor sleep and headaches can also be signs of the deficiency.

The current recommendations for vitamin D intake by the National Academy of Medicine are 600 IU per day for adults.

Foods that are rich in vitamin D include oily fish and eggs, but most people get their vitamin D from the action of sunlight on the skin.

Sufficient levels of vitamin D3 can help to restore the cardiovascular system, repairing damage done by diseases like hypertension and diabetes.

The conclusions come from a study that examined the impact of vitamin D3 on a vital component of the cardiovascular system, endothelial cells.

Professor Tadeusz Malinski, study co-author, said:

“Generally, Vitamin D3 is associated with the bones. However, in recent years, in clinical settings people recognize that many patients who have a heart attack will have a deficiency of D3.

It doesn’t mean that the deficiency caused the heart attack, but it increased the risk of heart attack.

We use nanosensors to see why Vitamin D3 can be beneficial, especially for the function and restoration of the cardiovascular system.”

The results showed that vitamin D3 can help to prevent blood clots and reduce oxidative stress in the cardiovascular system.

Getting sufficient levels of vitamin D could help to reduce the risk of heart attacks.

Professor Malinski said:

“There are not many, if any, known systems which can be used to restore cardiovascular endothelial cells which are already damaged, and Vitamin D3 can do it.

This is a very inexpensive solution to repair the cardiovascular system.

We don’t have to develop a new drug.

We already have it.”

The study was published in the International Journal of Nanomedicine (Khan et al., 2018).

The Common Signs Of Vitamin D Deficiency

Vitamin D supplementation could lower the risk of dying from cancer-related diseases and increase life expectancy by years.

Vitamin D supplementation could lower the risk of dying from cancer-related diseases and increase life expectancy by years.

Tiredness and weak muscles can be signs of vitamin D deficiency, as can headaches and poor sleep.

Taking vitamin D can reduce cancer mortality rates by 13 percent with 30,000 fewer cancer-related deaths each year, according to a German study.

Based on their national data on cancer mortality in 2016, vitamin D supplementation could significantly lower cancer deaths in adults over age 50.

They say if all these middle-aged Germans took vitamin D, nearly 30,000 premature deaths from cancer could be prevented and 300,000 years of life could be saved.

In recent years scientists have been looking into the effect of vitamin D on several conditions such as diabetes, inflammatory diseases, cancer, and respiratory illnesses.

Reviews of large clinical trials show that vitamin D supplementation is linked to a 13 percent reduction in the cancer death rate.

Dr Hermann Brenner, the study’s co-author, said:

“In many countries around the world, the age-adjusted rate of cancer mortality has fortunately declined over the past decade.

However, given the often considerable costs of many new cancer drugs, this success has often come at a high price.

Vitamin D, on the other hand, is comparatively inexpensive in the usual daily doses.”

Older people are commonly found to have vitamin D deficiency, particularly those with cancer.

In 2016, the number of people over-50 in Germany was about 36 million.

The research team calculated that the treatment cost of vitamin D supplementation at a 1,000 international units daily dose would cost 25 euros per person a year.

Considering its health benefits, the cost for the health care system would be practically nothing after all.

Dr Brenner, said:

“In view of the potentially significant positive effects on cancer mortality — additionally combined with a possible cost saving — we should look for new ways to reduce the widespread vitamin D deficiency in the elderly population in Germany.

In some countries, foods have even been enriched with vitamin D for many years — for example, in Finland, where cancer mortality rates are about 20 percent lower than in Germany.

Not to mention that there is mounting evidence of other positive health effects of adequate vitamin D supply, such as in lung disease mortality rates.

Finally, we consider vitamin D supplementation so safe that we even recommend it for newborn babies to develop healthy bones.”

We can all improve our vitamin D levels at no cost by exposure to sunlight everyday.

The German Cancer Research Centre recommends three times a week for at least 12 minutes outside in the sun.

During this period of time the face, hands, arms and legs should be left uncovered without wearing sunscreen.

The study was published in the journal Molecular Oncology (Niedermaier et al., 2021).

One Daily Serving Of This Food Slows Brain Aging By 11 Years

Eat up! They preserve your memory and thinking skills.

Eat up! They preserve your memory and thinking skills.

One daily serving of leafy green vegetables could preserve memory and thinking skills, research shows.

Older adults who ate at least one serving of these veggies were the equivalent of 11 years younger cognitively.

This was compared to those that ate few leafy green vegetables.

Dr Martha Clare Morris, the nutritional epidemiologist who led the study, said:

“Adding a daily serving of green leafy vegetables to your diet may be a simple way to help promote brain health.

There continues to be sharp increases in the percentage of people with dementia as the oldest age groups continue to grow in number.

Effective strategies to prevent dementia are critically needed.”

The study followed 960 people with an average age of 81, none of whom had dementia.

Their memory and thinking skills were tested once a year for around 5 years.

Each person reported how often they ate greens, including salad and lettuce.

When they were followed up, the results showed that the more leafy greens they ate, the better their cognitive health.

Dr Morris said:

“The study results do not prove that eating green, leafy vegetables slows brain aging, but it does show an association

The study cannot rule out other possible reasons for the link.

Because the study focused on older adults with the majority of participants being white, the results may not apply to younger adults and to people of color.

The results need to be confirmed by other investigators in different populations and through randomized trials to establish a cause-and-effect relationship between the eating leafy greens and reductions in the incidence of cognitive decline.”

The study was published in the journal Neurology (Morris et al., 2017).

Vitamin B12 Deficiency: The Facial Sign That May Be A Symptom

Around one-in-four people may have a vitamin B12 deficiency.

Around one-in-four people may have a vitamin B12 deficiency.

Pale skin or skin with a slight yellow tinge can be a sign of vitamin B12 deficiency.

The body uses vitamin B12 to make red blood cells and to keep the nervous system healthy.

Without enough B12 the blood cells produced are too large and cannot move into the bloodstream, leading to pale skin.

Around one-quarter of people may have a vitamin B12 deficiency.

Other, more common signs of vitamin B12 deficiency include feeling tired, experiencing muscle weakness and being constipated.

People experiencing a mood disorder, like depression, can also be deficient in vitamin B12.

People who may have difficulty getting enough vitamin B12 include vegetarians, older people and those with some digestive disorders, such as Crohn’s disease.

Some medications, such as those to treat ulcers and excessive stomach acid, are also linked to vitamin B12 deficiency.

One study of 25,956 patients diagnosed with a vitamin B12 deficiency found that the condition was linked to taking anti-acid medications.

The study’s authors write:

“Vitamin B12 deficiency is relatively common, especially among older adults; it has potentially serious medical complications if undiagnosed.

Left untreated, vitamin B12 deficiency can lead to dementia, neurologic damage, anemia, and other complications, which may be irreversible.”

Vitamin B12 deficiency is easy to rectify with supplements or by dietary changes.

Vitamin B12 levels can be boosted through supplementation or by eating foods such as dairy, liver, salmon and eggs.

Other good sources of vitamin B12 include poultry and low-fat milk.

Fortified breakfast cereals also contain vitamin B12.

The study was published in JAMA (Lam et al., 2013).

Think You Eat Healthily? 75% Of People Are Too Optimistic

How do people rate the quality of their diet and are they accurate?

How do people rate the quality of their diet and are they accurate?

Most people overrate their diet quality and sometimes they believe what they eat is very healthy, despite the reverse being true.

When American adults were asked about how healthy their diet was, three-quarters were too optimistic, a study reveals.

Dr Jessica Thomson, the study’s first author, said:

“We found that only a small percentage of U.S. adults can accurately assess the healthfulness of their diet, and interestingly, it’s mostly those who perceive their diet as poor who are able to accurately assess their diet.

Additionally, most adults overrate the quality of their diet, sometimes to a substantial degree.”

The research team wanted to know if a simple but effective question could be introduced as an assessment tool to complement or replace the food frequency questionnaires in nutritional studies.

Self-rated health is a single question like “how would you rate your general health? Excellent, very good, good, fair, or poor?”.

It is well known that self-rated health is a good predictor of diseases, illnesses and death.

But it is not clear if self-rated diet could foresee how good people’s diet is.

85% were incorrect

The team analysed data from 9,700 American adults in the National Health and Nutrition Examination Survey.

They found that 85 percent of participants scored their diet quality incorrectly.

About 75 percent considered their diet healthier than it was and 63 percent rated their diet quality as “very good”.

Only 15 percent of adults were accurate — surprisingly it was those who had rated their diet quality as “poor”.

Women, adults with lower income, and those with lower education were more likely to value their diet quality correctly.

Dr Thomson said:

“It’s difficult for us to say whether U.S. adults lack an accurate understanding of the components of a healthful versus unhealthful diet or whether adults perceive the healthfulness of their diet as they wish it to be — that is, higher in quality than it actually is.

Until we have a better understanding of what individuals consider when assessing the healthfulness of their diet, it will be difficult to determine what knowledge and skills are necessary to improve self-assessment or perception of one’s diet quality.”

Related

  • What you eat has a bigger impact on your health than any powerful drug.
  • The Green Med diet leads to more weight loss and improves heart health.
  • People fed a healthier diet from an early age have a higher IQ.
  • Women’s mental health is more sensitive to what they eat than men’s.

The study was published in the American Journal of Health Promotion (Thomson et al., 2022).

8 Simple Steps To Live 10 Years Longer

Live a decade longer and be free from chronic illnesses by following 8 heart healthy metrics.

Live a decade longer and be free from chronic illnesses by following 8 heart healthy metrics.

Paying attention to 8 cardiovascular health factors will considerably increase life expectancy, research suggests.

In this study, adults with higher scores for 8 cardiovascular health metrics lived nearly a decade longer than those who scored poorly.

The metric is known as Life’s Essential 8 and has been developed by the American Heart Association.

It is based on a scoring system which measures a set of health factors and lifestyle behaviours.

To estimate people’s life expectancy, the research team assessed cardiovascular health levels based on the Life’s Essential 8 score, which consists of:

  1. a healthy diet,
  2. physical activity,
  3. not smoking,
  4. correct sleep duration,
  5. maintaining a healthy weight,
  6. controlling cholesterol,
  7. healthy blood glucose,
  8. and healthy blood pressure.

Another study previously suggested that people who committed to these metrics lived longer and were more healthy.

According to the study’s senior author, Professor Lu Qi, the findings indicate:

“That you can modify your lifestyle to live longer.”

More than 23,000 adults participated in this study with an eight-year follow up.

The scoring system ranged from zero to 100 points, from low as below 50, moderate as 50 to 79, and high as 80 or higher.

Compared to adults who scored lowest, those who scored 80 or higher, at age 50 had a life expectancy of nine more years.

Smoking, sleep, blood glucose levels, and physical activity appeared to be the most important life expectancy factors.

Non-smokers lived 7.4 years longer than those who were heavy smokers.

Participants who slept between seven to nine hours a night lived five more years compared to those with either not enough or too much sleep.

Higher score for maintaining blood glucose levels showed a life expectancy of 4.9 more years.

A life expectancy of 4.6 more years was seen in people with higher physical activity than those with the least.

Professor Nathan Wong, a cardiovascular epidemiologist, commenting on this study, said:

“Information on psychosocial factors such as stress and depression, as well as on social determinants of health such as access to health care, may also play an important role and modify the impact that the key cardiovascular health metrics have on cardiovascular and non-cardiovascular outcomes.

As the study looked exclusively at mortality, effects on non-fatal cardiovascular outcomes should also be examined, given their substantial impact on health care utilization.”

Related

The study was published in the journal Circulation (Ma et al., 2023).

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