Manic episodes can lead to dangerous risk-taking and delusional thinking — it frequently requires hospitalisation.
Eating processed meats like beef jerky and salami is linked to manic episodes.
Manic episodes are a symptom of bipolar disorder and involve becoming euphoric, restless, experiencing a reduced need for sleep and having a racing mind.
Manic episodes can lead to dangerous risk-taking and delusional thinking — it frequently requires hospitalisation.
People who ate nitrate-cured meats were 3.5 times more likely to be hospitalised for mania as those who had not eaten the food, the researchers found.
Professor Robert Yolken, study co-author, said:
“We looked at a number of different dietary exposures and cured meat really stood out.
It wasn’t just that people with mania have an abnormal diet.”
The results come from 1,101 people with and without psychiatric disorders.
It wasn’t clear from this study how much cured meat was linked to mania.
However, the researchers also carried out a lab study on rats.
Some they fed store-bought beef-jerky and these started to show signs of mania within two weeks of eating the meat.
Professor Yolken said:
“We tried to make sure the amount of nitrate used in the experiment was in the range of what people might reasonably be eating.”
The scientists also tried feeding the rats nitrate-free meat — these did not show symptoms of mania, suggesting it was the nitrate causing the problem.
While small amounts of cured meats are unlikely to set off manic episodes in humans, further research is required.
Ms Seva Khambadkone, the study’s first author, said:
“It’s clear that mania is a complex neuropsychiatric state, and that both genetic vulnerabilities and environmental factors are likely involved in the emergence and severity of bipolar disorder and associated manic episodes.
Our results suggest that nitrated cured meat could be one environmental player in mediating mania.”
The researchers think that bacteria in the gut mediate the link between nitrates and mania.
Professor Yolken said:
“There’s growing evidence that germs in the intestines can influence the brain.
And this work on nitrates opens the door for future studies on how that may be happening.”
The study was published in the journal Molecular Psychiatry (Khambadkone et al., 2018).