Depression Linked To Pea-Sized Brain Structure That Backfires

An area of the brain that tracks negative events newly linked to depression.

An area of the brain that tracks negative events newly linked to depression.

A brain structure that tracks negative events backfires in depression, a new study finds.

The habenula — a structure the size of a pea — reacts strangely to negative events, researchers have found.

It could help explain a common symptom of depression: dwelling on negative memories.

Professor Jonathan Roiser, one of the study’s authors, said:

“A prominent theory has suggested that a hyperactive habenula drives symptoms in people with depression: we set out to test that hypothesis.

Surprisingly, we saw the exact opposite of what we predicted.

In people with depression, habenula activity actually decreased when they thought they would get a shock.

This shows that in depressed people the habenula reacts in a fundamentally different way.

Although we still don’t know how or why this happens, it’s clear that the theory needs a rethink.”

The results come from comparing brain scans (fMRI) of 25 people with depression with those of 25 people who never experienced depression.

Dr. Rebecca Lawson, the study’s first author, said:

“The habenula’s role in depression is clearly much more complex than previously thought.

From this experimental fMRI study we can draw conclusions about the effects of anticipated shocks on habenula activation in depressed individuals compared with healthy volunteers.

We can only speculate as to how this deactivation is linked to symptoms, but it could be that this ancient part of the brain actually plays a protective role against depression.

Animal experiments have shown that stimulating the habenula leads to avoidance, and it is possible that this occurs for mental as well as physical negative events.

So one possible explanation is that the habenula may help us to avoid dwelling on unpleasant thoughts or memories, and when this is disrupted you get the excessive negative focus that is common in depression.”

The study was published in the journal Molecular Psychiatry (Lawson et al., 2016).

Brain image from Shutterstock

Antibiotics Hurt Memory And Slow Brain Cell Growth

262 million prescriptions are written for antibiotics in one year in the US alone.

262 million prescriptions are written for antibiotics in one year in the US alone.

Antibiotics that are strong enough to kill the gut bacteria also stop new brain cells growing.

Scientists have found that brain cell growth in the hippocampus — a region vital for memory — is slowed by prolonged antibiotic use.

The effects can be countered, however, with exercise and probiotics.

Dr Susanne Asu Wolf, a senior study author, said:

“We found prolonged antibiotic treatment might impact brain function.

But probiotics and exercise can balance brain plasticity and should be considered as a real treatment option.”

In the research mice were given enough antibiotics to clear out their intestines of all microbes.

Their memories and brains were then compared with untreated mice.

The researchers found that mice who lost their healthy gut bacteria performed worse on the memory tests.

They also showed deficits in their ability to produce new brain cells.

The adverse effects, though, could be reversed.

Mice who were given probiotics and who exercised recovered both their memory and their ability to create new brain cells.

Dr Wolf said:

“The magnitude of the action of probiotics on Ly6Chi cells, neurogenesis, and cognition impressed me.”

Many studies are now showing the importance of ‘good’ intestinal bacteria for our mental health.

“Bacteria in the intestine can play an important role in causing anxiety and depression, new research concludes.

It helps explain recent research suggesting probiotics can stop sad moods getting worse.

Probiotics may work to help stabilise the bacteria in the gut.

Another recent study also found probiotics may reduce anxiety.”

And antibiotics have also been linked to mental confusion and even delirium in some patients.

The study was published in the journal Cell Reports (Möhle et al., 2016).

Running Like This Improves Memory In 15 Minutes

Working memory improved in just 15 minutes.

Working memory improved in just 15 minutes.

Running barefoot improves memory more than running with shoes on, a new study finds.

The benefits may come from the extra demands placed on the brain while barefoot running.

For example, you have to avoid stones and anything else that may damage your feet.

The type of memory tested in the study is called ‘working memory’.

The brain uses working memory to recall and process information.

Dr Tracy Alloway, the study’s first author, said:

“Working memory is increasingly recognized as a crucial cognitive skill, and these findings are great news for people looking for a fun way to boost their working memory.”

The study had 72 people running either barefoot of with shoes for about 15 minutes.

People ran at whatever pace was comfortable with them.

Memory tests afterwards showed that those running barefoot scored 16% better on working memory tests.

Dr Alloway continued:

“The little things often have the greatest impact.

This research shows us that we can realize our cognitive potential and enjoy ourselves at the same time.

If we take off our shoes and go for a run, we can finish smarter than when we started.”

The study was published in the journal Perceptual and Motor Skills (Alloway et al., 2016).

Barefoot image from Shutterstock

The Common Infection Linked To Mental Illness And Memory Problems

Men with schizophrenia or bipolar disorder were more likely to have a history of this infection.

Men with schizophrenia or bipolar disorder were more likely to have a history of this infection.

Candida yeast infections are linked to serious mental health problems, new research finds.

Men with schizophrenia or bipolar disorder were more likely to have a history of infection.

Women with schizophrenia or bipolar disorder who also had a Candida infection were more likely to have poorer memory.

Dr Emily Severance, the study’s first author, said:

“It’s far too early to single out Candida infection as a cause of mental illness or vice versa.

However, most Candida infections can be treated in their early stages, and clinicians should make it a point to look out for these infections in their patients with mental illness.”

Nevertheless, the study suggests there are critical links between psychiatric disorders, memory problems and yeast infections.

Candida infections can be tackled by washing properly, lowering sugar intake and avoiding unnecessary antibiotics.

Candida albicans is a fungus which naturally occurs in the human digestive tract.

It can cause rashes as well as sexually transmittable yeast infections.

Dr Severance said:

“Although we cannot demonstrate a direct link between Candida infection and physiological brain processes, our data show that some factor associated with Candida infection, and possibly the organism itself, plays a role in affecting the memory of women with schizophrenia and bipolar disorder, and this is an avenue that needs to be further explored.

Because Candida is a natural component of the human body microbiome, yeast overgrowth or infection in the digestive tract, for example, may disrupt the gut-brain axis.

This disruption in conjunction with an abnormally functioning immune system could collectively disturb those brain processes that are important for memory.”

The study was published in the journal npj Schizophrenia (Severance et al., 2016).

Study: 4 Herbs That Influence Both Mood And Memory

Research finds the herbs that can improve mood, memory and induce calmness.

Research finds the herbs that can improve mood, memory and induce calmness.

Chamomile, peppermint, rosemary and lavender can all affect mood and memory, new research finds.

Peppermint tea can improve alertness while chamomile does indeed provide a calming effect.

Smelling rosemary, meanwhile, improved the memories of people over 65 by an average of 15%.

Lavender, though, impaired their memory.

The conclusions come from a series of studies which compared memory and thinking skills before and after exposure to various  herbs.

Dr Mark Moss, one of the study’s authors, said:

“Peppermint has a reputation for being psychologically or mentally alerting.

It picks you up and makes you feel a little bit brighter, so we endeavoured to test this out by giving people peppermint tea, or chamomile tea, which is a more calming drink and then put them through some computerised tests.

We found that those people who had drunk the peppermint tea had better long-term memory.

They were able to remember more words and pictures that they had seen.

Dr Moss continued:

“In contrast, the people who had the chamomile were slower in responding to tasks.

Rosemary meanwhile has a reputation about being associated with memory – even Shakespeare said ‘rosemary is for remembrance’ – and it’s also associated with being invigorating.

We have found that people are more alert after being in a room that has rosemary aroma in it.

We tested prospective memory – our ability to remember to remember to do something – on people over 65 years of age, to see if we could improve their ability and we found that rosemary could do that.

This is potentially very important because prospective memory, for example, enables you to remember to take your medication at certain times of the day.

Dr Moss said the varied results for different herbs were interesting:

“It is interesting to see the contrasting effects that different herbs can have on both mood and memory, and our research suggests that that they could have beneficial effects, particularly in older age groups.

If you were otherwise healthy then this research suggests that there is an opportunity to have an improved memory.”

The findings were presented at the annual British Psychological Society Conference in Nottingham (26-28 April 2016).

You Can Remember More Words With This Imagery Strategy

Study tests effects of mental imagery on memory.

Study tests effects of mental imagery on memory.

Mental imagery is an effective way to improve memory and reduce some false memories, new research finds.

People in the study who were told to create images for words were better able to remember them.

Images also helped people avoid false memories.

Ms Merrin Oliver, the study’s first author, said:

“Creating images improved participants’ memories and helped them commit fewer errors, regardless of what kind of list we gave them.”

False memories can be related to misremembering the source, Ms Oliver explained:

“We aren’t good at judging the source of our memories.

These lists usually remind people of a word that they didn’t actually study, so they mistakenly recollect studying words similar to those on the list.”

For the research, one group were told to use imagery to remember a list of words while the other were just told to remember the words.

Ms Oliver said:

“Our study suggests more detailed imagery instructions are necessary to help filter out false memories during a recognition test, where false memories are typically very high.

People should create detailed images with unique characteristics to help avoid the endorsement of false memories on recognition-based tests like true/false or multiple-choice assessments, where you are tempted by lures and possible false memories.”

The study was published in The Journal of General Psychology (Oliver et al., 2016).

How Memory Works: 21 Psychological Insights

Brain image from Shutterstock

How To Write Down Notes You Will Remember

Study compares writing by hand with real and virtual keyboards.

Study compares writing by hand with real and virtual keyboards.

Writing by hand strengthens memory in comparison to writing on a real or virtual keyboard, new research finds.

The motor feedback from the process of writing along with the sense of touching paper and pen helps people learn.

Areas of the brain vital to language are more strongly activated by the physical activity.

The study compared 36 people writing in three different ways:

  • on a conventional keyboard,
  • on a virtual keyboard (like an iPad),
  • or handwriting.

They were read a list of words which they wrote down.

Their memory for the words was then tested for both free recall and recognition.

The results showed that the method of writing down the words did not effect recognition, but free recall was better for handwriting.

Since it is much harder to recall a word than to recognise it, memory was stronger for handwritten words.

The authors explain the study’s results:

“…keyboard writing per se (whether on a virtual or a conventional keyboard) attenuates or disrupts memory for what is written.

However, with respect to aspects of word recall, our findings indicate that there may be certain cognitive benefits to handwriting which may not be fully retained in keyboard writing.”

The advantage of handwriting is that the attention is all on the same thing at the same time.

The study’s authors think the problem with keyboard writing could be partly down to a split in attention:

“The visual attention of keyboard writers is split between looking at the emerging text and looking at the keyboard on which they write.

From a visual-spatial perspective, a keyboard separates the “motor area” (or input area) where the letters are being produced (the keyboard) from the visual presentation area of the letters (the screen; or output area).

A keyboard thereby provides less real-time sensory and visual information about the writer’s own writing process, a fact which may result in less robust mental representations of the words.

One consequence of such a separation may be that the writer engages less with the written text and consequently is provided with an attenuated visual memory of the word, than in the handwriting condition, where the subject may fixate near the point where the physical writing takes place.”

The study was published in the Journal of Writing Research (Mangen et al., 2016).

Handwriting image from Shutterstock

The Safe Gas That Helps Stop Distressing Memories From Getting Stuck In The Mind

The experience of distressing, intrusive memories was reduced by over a half.

The experience of distressing, intrusive memories was reduced by over a half.

Inhaling laughing gas after a traumatic event reduces the later intrusion of distressing memories, new research finds.

People who inhaled nitrous oxide experienced fewer intrusive thoughts a day later, the study found.

Dr Ravi Das, the study’s first author, explained:

“The day after they saw the film, the number of intrusions experienced by the group who received nitrous oxide fell by over a half.

By contrast, the decline in intrusions was much slower in the group who received air, where there was not a significant drop in intrusions until the fourth day.

We think that this is because nitrous oxide disrupts a process that helps permanent memories to form.”

The study involved participants watching a distressing video clip.

Afterwards, half were given air, the other half a mixture containing the laughing gas.

Dr Das said:

“On any given day your brain will be exposed to a huge amount of information, some important, but most trivial.

If information is ‘important’ enough to remember, for instance because it produces a strong emotional response, it is ‘tagged’ for storage.

The brain requires N-Methyl D-Aspartate (NMDA) receptors to tag information during the day, which is then filed for long-term storage while we sleep.

We know that nitrous oxide blocks NMDA receptors, so could interfere with tagging.

This might explain why the nitrous oxide group seemed to have weaker memories of the film the day after they watched it.”

Dr Sunjeev Kamboj, one of the study’s co-authors, said:

“Nitrous oxide is routinely used as a painkiller by paramedics and in A&E departments because it is safe and easy to administer.

Many people who end up in an ambulance will have undergone some form of psychological trauma, and our study suggests that the nitrous oxide is likely to be having some effect on how their brain processes it.

However, whether it helps to prevent symptoms of PTSD or makes them more likely may depend on how dissociated patients feel before they receive it.

Further research is now needed to determine whether dissociation similarly affects the response of trauma victims who receive nitrous oxide or other painkillers such as ketamine.

It is worth noting that our volunteers were given nitrous oxide continuously for half an hour, whereas the amount that hospital patients receive will vary significantly.

Some may only receive small doses in the ambulance whereas others could be breathing it on-and-off for hours in a hospital bed.

Any effects, positive or negative, are also likely to vary depending on the dose.

The amount of nitrous oxide used recreationally in a balloon, for example, would likely be too small to have a noticeable effect on memory formation.”

The study was published in the journal Psychological Medicine (Das et al., 2016).

Sad man image from Shutterstock

Memory And Attention Work Best At Certain Times Of The Year, Study Finds

New research suggests people’s cognitive abilities are affected by the seasons.

New research suggests people’s cognitive abilities are affected by the seasons.

Brain scans show that people’s short-term memory is generally best in fall (autumn) and worst in spring.

In mid-December, though, people’s attention skills are at their lowest ebb.

Attention doesn’t come up to full strength until June.

Dr Gilles Vandewalle, one of the study’s authors, said that the causes are likely down to multiple factors, but:

“…we may be tuned to lower brain activity in winter, and that could cause changes in brain activity.

But in modern society we are similarly active throughout the year.”

It could also be that people who experience seasonally affected disorder may be particularly vulnerable to changes in cognition over the year.

Brain Scans Reveal Why Up To One in Six People Get SAD in Winter

The new research had 28 men and women visit the lab at different times of the year to take various tests.

Both brain scans and behavioural tests were used.

Only the brain scans showed the differences, not the behavioural tests.

The study was published in the journal PNAS (Meyer et al., 2016).

Image credit: Noukka Signe

Learning and Memory Skills Can Recover From The Diet That Damages Them

Certain diets can damage learning and memory, but the brain can recover, a new study finds.

Certain diets can damage learning and memory, but the brain can recover, a new study finds.

High-fat diets have long been linked to all kinds of psychological problems, including depression, anxiety and learning and memory deficits.

Now, research on mice has found that memory and learning problems disappear over time, even while maintaining the high-fat diet.

In the study, some of the mice were fed a high-fat diet.

Compared with another group fed a normal diet, after three months they showed severe problems with spatial memory.

But, after 12 months, their brains seemed to have adjusted to the high-fat diet.

High-Fat Diet May Disturb a Range of Thoughts And Feelings

Ms Erica Underwood, one of the study’s author, said:

“Other factors behind the impairment must be recovering in the long term.

That’s the beautiful thing about the brain.

It can often recover or find alternate routes to allow normal function in spite of impairment.”

While the mice’s brains coped with the diet, their bodies fared less well.

The high-fat diet caused obesity and the males developed the symptoms of type-2 diabetes.

Professor Lucien Thompson, who co-authored the study, said:

“We saw that the males’ brains, as well as bodies, became insulin-insensitive.

They were producing more insulin because of the fatty diet, but not enough to cover blood glucose surges after an oral dose of glucose.

And while insulin normally stimulates hippocampal neurons, high-fat diet males stopped responding to insulin.”

Ms Underwood concluded:

“For the first time in human history we have large numbers of toddlers who are severely overweight.

It’s unprecedented.

With this new type of physiology we’re seeing, we don’t really know what’s going to happen to these children 20 or 50 years from now.”

The study was published in the journal Neural Plasticity (Underwood & Thompson, 2015).

I am busy image from Shutterstock

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