Autism And ADHD May Double Risk Of Early Death

The link between autism and early death appears to be mostly due to natural causes.

The link between autism and early death appears to be mostly due to natural causes.

Having either ADHD or autism comes with a higher risk of dying early, a large study finds.

According to a review of the results of 27 separate studies, people with autism or ADHD are at double the risk of an early death.

The causes of death are both natural and unnatural.

Natural causes of death include seizures and cardiac events, while unnatural deaths include accidents and suicide.

ADHD and early death

ADHD, which affects around 5 percent of people, appears to be particularly strongly linked to unnatural deaths.

People with ADHD are at a high risk of death from accidents, a previous study on the same subject found (Dalsgaard et al., 2015)

Earlier diagnosis, though, tended to be a protective factor.

Those not diagnosed with ADHD until after they were 18 were at four times the risk of an early death, with females being particularly vulnerable.

Dr Søren Dalsgaard, the study’s first author, said:

 “Our findings emphasise the importance diagnosing ADHD early, especially in girls and women, and treating any co-existing antisocial and substance use disorders.

It is however important to emphasise that although the relative risk of premature death is increased in ADHD, the absolute risk is low.”

Autism and early death

The link between autism and early death appears to be mostly due to natural causes.

For example, people with autism are more likely to suffer from other mental health problems like depression, anxiety, eating disorders, conduct and tic disorders.

People with these problems are also more likely to be sedentary, to take little exercise, to be obese and have heart disease and other medical problems.

Professor Stephen Faraone, an expert on ADHD and related disorders, said:

“Although talk of premature death will worry parents and patients, they can seek solace in the knowledge that the absolute risk for premature death is low and that this and other risks can be greatly reduced with evidenced-based treatments for the disorder.”

The study was published in the journal JAMA Pediatrics (Catalá-López et al., 2022).

Autism Caused By Extreme Positive Personality Traits, Theory Argues (M)

Autism, experienced by around one-in-50 people, is caused by extreme levels of socially valued personality traits.

Autism, experienced by around one-in-50 people, is caused by extreme levels of socially valued personality traits.

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The Emotion People With Autism Have Difficulty Reading (M)

It is a myth that people with autism cannot read emotions, however there is one they have difficulty with.

It is a myth that people with autism cannot read emotions, however there is one they have difficulty with.

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The Vitamin Deficiency Linked To Autism (M)

Scientists think the problematic social behaviour of people with autism is related to this vitamin deficiency.

Scientists think the problematic social behaviour of people with autism is related to this vitamin deficiency.

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Autism Reversed In Only In 3 Days. Effects May Last Years.

The drug had no obvious side-effects.

The drug had no obvious side-effects.

A drug used to treat cancer could reverse the symptoms of autism in three days, new research finds.

Mice with autism given the drug showed a reversal in the social symptoms of autism.

The drug’s effects lasted three weeks, which in human terms is several years — so the drug appears long-lasting.

The drug — called romidepsin — is approved for fighting cancer by the US Food and Drug Administration.

Professor Zhen Yan, who led the study, said:

“We have discovered a small molecule compound that shows a profound and prolonged effect on autism-like social deficits without obvious side effects, while many currently used compounds for treating a variety of psychiatric diseases have failed to exhibit the therapeutic efficacy for this core symptom of autism.”

Previous studies have shown that autism suppresses the effects of over 200 genes and romidepsin restores most of these.

Professor Yan said:

“Autism involves the loss of so many genes.

To rescue the social deficits, a compound has to affect a number of genes that are involved in neuronal communication.”

The discovery relies on the fact that risk genes for autism and cancer overlap.

Professor Yan said:

“The extensive overlap in risk genes for autism and cancer, many of which are chromatin remodeling factors, supports the idea of repurposing epigenetic drugs used in cancer treatment as targeted treatments for autism.”

The study was published in the journal Nature Neuroscience (Qin et al., 2018).

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